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91.
Quantitative Detection for Porphyromonas gingivalis in Tooth Pocket and Saliva by Portable Electrochemical DNA Sensor Linked with PCR 下载免费PDF全文
Keiichiro Yamanaka Shinichi Sekine Takahiro Uenoyama Masahiro Wada Tomohiko Ikeuchi Masato Saito Yoshinori Yamaguchi Eiichi Tamiya 《Electroanalysis》2014,26(12):2686-2692
Here, a quantitative electrochemical analysis of periodontal bacteria in gingival crevicular fluid (GCF) and saliva by direct polymerase chain reaction (PCR) is presented. The electrochemical measurement was performed by mixing with PCR products and electrochemical indicator (bisbenzimidazole trihydrochloride). The peak current of indicator is reduced due to slower diffusion when the dye intercalates into the amplified DNA, and the degree of reduction in the peak current is correlates with the quantity of amplified DNA. Therefore, a quantitative analysis is possible by using our electrochemical method at the end point of PCR. In the GCF testing, The number of Porphyromonas gingivalis (Pg) detected by our electrochemical method at the end point of PCR were almost same compared with that were calculated by the conventional method of quantitative real? time PCR. In the saliva testing, the relationship between number of Pg in saliva and average pocket depth, and age‐dependence were also clearly observed. Since the saliva sample is obtained in a non‐invasive manner, this method is useful for the primary screening of periodontal disease. Moreover, our detection method is simple and uses a hand‐held potentiostat making it suitable for development of an on‐site periodontal diagnosis system. 相似文献
92.
Single-component molecular conductors [M(tmdt)2] (tmdt = trimethylenetetrathiafulvalenedithiolate; M = Ni, Au, Pt, Cu), exhibit a variety of electromagnetic properties, which originate from the differences of the metal’s d-orbitals role in the band structure formation. The [Au(tmdt)2] crystal undergoes an antiferromagnetic transition at 110 K, while maintaining a metallic state at lower temperatures. The Au analog has a high magnetic transition temperature as compared to traditional magnetic molecular conductors due to the strong three-dimensional (3-D) structure and the contribution of the metal d-orbitals. The single-component molecular conductor, [Cu(tmdt)2], with π- and d-like frontier orbitals is isostructural with other metallic [M(tmdt)2] systems (M = Ni, Pt, Au). The Cu(tmdt)2 molecule is planar, which strikingly contrasts the tetrahedral coordination of Cu(dmdt)2 (dmdt = dimethyltetrathiafulvalenedithiolate) with similarly extended TTF type ligands. Interestingly, unlike other [M(tmdt)2] with metallic behavior, [Cu(tmdt)2] shows semiconducting behavior at room temperature (σ(RT) = ∼7 S cm−1). The RT conductivity increased linearly with increased pressure to 110 S cm−1 at 15 kbar despite the compressed pellet sample. The magnetic susceptibility indicates one-dimensional (1-D) Heisenberg behavior with J = 117 cm−1 and shows antiferromagnetic ordering at 13 K. The [Cu(tmdt)2] is a new multi-frontier π-d system, which introduces a d(σ)-type frontier orbital around the Fermi level of the π-like metal bands. 相似文献
93.
Yoshinori Inoue Waka Kamichatani Mitsuru Saito Yasuyuki Kobayashi Atsushi Yamamoto 《Chromatographia》2011,73(9-10):849-855
A novel water-holding adsorbent was synthesized by introducing a zwitter-ionic polymer to a hydrophilic methacrylate base resin. The retention abilities of the hydrophilic compounds on the adsorbents with and without cross-link in the zwitter-ionic functional groups were examined. The amount of held water on the non-cross-linked adsorbent was higher than that of the cross-linked one. The extraction efficiencies of the hydrophilic solutes on the adsorbents were evaluated by the solid phase extraction method. These adsorbents showed high affinity for nucleosides and glycosides, and good recoveries for such hydrophilic compounds in the solid-phase extraction were obtained. Furthermore, the retention properties of the hydrophilic solutes on the adsorbents were also evaluated by LC. The hydrophilic solutes were retained on these adsorbents by a partition mode based on a hydrophilic interaction. The retention factors of the hydrophilic solutes showed good correlation to their log P o/w (logarithm of octanol?Cwater partition coefficient) and good separation based on hydrophilic interaction was obtained for nucleobases and nucleosides. 相似文献
94.
Eiichi Masumoto Hiroshi Maruoka Fumi Okabe Sho Nishida Yuki Yoshimura Toshihiro Fujioka Kenji Yamagata 《Journal of heterocyclic chemistry》2011,48(1):96-104
Dihydropyridazinones 4a , 4b , N‐substituted dihydropyrazoles 5b , 5c , 5d , and O‐substituted pyrazoles 6a , 6b , 6c , 6d have been synthesized starting from spirocyclopropanepyrazole derivative 2 . Treatment of 2 with α‐chloro esters, e.g., methyl chloroacetate, ethyl chloroacetate, isopropyl chloroacetate, and tert‐butyl chloroacetate, in potassium carbonate/sodium iodide system caused ring opening and subsequent C‐ or N‐attack nucleophilic substitution to give the corresponding dihydropyridazinones 4a , 4b and N‐substituted dihydropyrazoles 5b , 5c , 5d . On the other hand, in the absence of sodium iodide, O‐substituted pyrazoles 6a , 6b , 6c , 6d were obtained from 2 via an O‐attack nucleophilic substitution. J. Heterocyclic Chem., 2011. 相似文献
95.
Hidetsura Cho Yoshio Nishimura Yoshizumi YasuiSatoshi Kobayashi Shin-ichiro Yoshida Eunsang Kwon Masahiko Yamaguchi 《Tetrahedron》2011,67(14):2661-2669
Synthesis of novel 4-unsubstituted dihydropyrimidines (DPs) was performed. Subsequently, a variety of 4-unsubstituted 1,4(3,4)-DPs with amino moieties at position-2 were obtained in excellent yields by activation of position-2 owing to regioselective alkoxycarbonylation at position-3 of the DP skeleton. 3-Oxo-2-phenyl-2,3,5,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrimidine was obtained using phenylhydrazine instead of amines. Individual tautomers of 1,4(3,4)-DP were observed in the 1H NMR spectra of one derivative depending on temperature and concentration. On the other hand, only 1,4-DP was found in the solid state by single-crystal X-ray crystallography. 相似文献
96.
Narihito OgawaYuichi Kobayashi 《Tetrahedron letters》2011,52(23):3001-3004
Stereoselective total synthesis of protectin D1 was completed through construction of the Z,E,E-triene structure by using the Suzuki coupling between the vinyl borane (C13-C22) and the vinyl iodide (C1-C12). The Z-enyne, the acetylene precursor of the vinyl borane was synthesized from optically active γ-TMS allylic alcohol in a straightforward way. On the other hand, the vinyl iodide was prepared by using Wittig reaction between the C8-C12 aldehyde possessing the requisite iodo-olefin moiety and the C1-C7 phosphonium iodide. 相似文献
97.
Dr. Hua Lu Dr. Soji Shimizu Dr. John Mack Prof. Zhen Shen Prof. Nagao Kobayashi 《化学:亚洲杂志》2011,6(4):1026-1037
A series of fused‐ring‐expanded aza‐boradiazaindacene (aza‐BODIPY) dyes have been synthesized by reacting arylmagnesium bromides with phthalonitriles or naphthalenedicarbonitriles. An analysis of the structure–property relationships has been carried out based on X‐ray crystallography, optical spectroscopy, and theoretical calculations. Benzo and 1,2‐naphtho‐fused 3,5‐diaryl aza‐BODIPY dyes display markedly red shifted absorption and emission bands in the near‐IR region (>700 nm) due to changes in the energies of the frontier MOs relative to those of 1,3,5,7‐tetraaryl aza‐BODIPYs. Only one 1,2‐naphtho‐fused aza‐BODIPY of the three possible isomers is formed due to steric effects, and 2,3‐naphtho‐fused compounds could not be characterized because the final BF2 complexes are unstable in solution. The incorporation of a N(CH3)2 group at the para‐positions of a benzo‐fused 3,5‐diaryl aza‐BODIPY quenches the fluorescence in polar solvents and results in a ratiometric pH response, which could be used in future practical applications as an NIR “turn‐on” fluorescence sensor. 相似文献
98.
Dr. Yasuhiro Yamashita Takaki Imaizumi Dr. Xun‐Xiang Guo Prof. Dr. Shū Kobayashi 《化学:亚洲杂志》2011,6(9):2550-2559
Asymmetric [3+2] cycloaddition of α‐aminoester Schiff bases with substituted olefins is one of the most efficient methods for the preparation of chiral pyrrolidine derivatives in optically pure form. In spite of its potential utility, applicable substrates for this method have been limited to Schiff bases that bear relatively acidic α‐hydrogen atoms. Here we report a chiral silver amide complex for asymmetric [3+2] cycloaddition reactions. A silver complex prepared from silver bis(trimethylsilyl)amide (AgHMDS) and (R)‐DTBM‐SEGPHOS worked well in asymmetric [3+2] cycloaddition reactions of α‐aminoester Schiff bases with several olefins to afford the corresponding pyrrolidine derivatives in high yields with remarkable exo‐ and enantioselectivities. Furthermore, α‐aminophosphonate Schiff bases, which have less acidic α‐hydrogen atoms, also reacted with olefins with high exo‐ and enantioselectivities. The stereoselectivities of the [3+2] cycloadditions with maleate and fumarate suggested that the reaction proceeded by means of a concerted mechanism. An NMR spectroscopic study indicated that complexation of AgHMDS with the bisphosphine ligand was not complete, and that free AgHMDS, which did not show any significant catalytic activity, existed in the catalyst solution. This means that significant ligand acceleration occurred in the current reaction system. 相似文献
99.
Application of 28Mg for characterization of Mg uptake in rice seedling under different pH conditions
N. I. Kobayashi N. Iwata T. Saito H. Suzuki R. Iwata K. Tanoi T. M. Nakanishi 《Journal of Radioanalytical and Nuclear Chemistry》2013,296(1):531-534
The magnesium (Mg) uptake of rice seedlings treated with different pH solutions was investigated using tracer of 28Mg. The application of 28Mg enabled the determination of Mg uptake amount within 15 min of the different pH treatments. The uptake amount of 28Mg and its distribution in rice plants were determined by using the imaging plate. The result demonstrated that the Mg uptake amount was approximately 3 μmol/15 min per plant in 0.27 mM Mg solution at pH 5.6, and this uptake decreased by 30 % at lower pH conditions (pH 4.5). On the contrary, the pH 6.5 condition induced the Mg uptake activity to 4.4 μmol/15 min. The inverse relationship found between proton concentration in nutrient solution and the Mg uptake amount within 15 min of treatment demonstrated that the low pH condition could inhibit the Mg uptake activity as a consequence of the competition between Mg2+ and proton. It is concluded that under low pH conditions, regardless of other factors, there is a decrease of Mg uptake activity in rice roots. 相似文献
100.
An intramolecular aromatic oxidation of a phenolic compound with a hypervalent iodine reagent afforded the coupling product, in which the coupling took place at the para-position of the methoxy goup of the starting material instead of the desired para-position of the isopropenyl group, unfortunately. 相似文献